CD43 mFluor™ 450

The clone C-E7A3, recognizes cell surface protein antigen having molecular weight 115-130 kDa known as CD43 (also known as sialophorin or leukosialin). Sialophorin is a major sialoglycoprotein present on the surface of human T lymphocyte, monocytes, granulocyte, and some of B lymphocytes, which regulates multiple immune function and may be part of a physiological ligand-receptor complex involved in T-cell activation. Therefore, the CD43 expression can be observed at high levels on all leukocytes except for most resting B lymphocytes. In hematopathology, CD43 is often considered as a T-cell associated marker as it is expressed by over 95% of thymocytes and peripheral blood T cells.